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- Title
Stem cells as regenerative medicine targeting cardiovascular diseases: Covenant, Contingency and Challenges.
- Authors
Parikh, Shivang; Desai, Bakul; Gandhari, Mukesh; Desai, Jignesh
- Abstract
Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Repair of the heart is an old dream of physicians caring for patients with cardiac disease. There is now growing evidence that the human heart is capable of undergoing repair and in recent years there has been an increase in basic and clinical research with the aim of harnessing the regenerative properties of stem cells in order to facilitate restoration of myocardial function. Experimental studies suggest that cardiac transfer of stem and progenitor cells can have a favorable impact on tissue perfusion and contractile performance of the injured heart. For advancement several important aspects need to be addressed in carefully designed comparative studies which allow discriminating superior cell populations, time, dosage and delivery route and mode for different applications in patients with acute myocardial infarction, advanced coronary artery disease, and chronic heart failure. The overall clinical experience also suggests that stem cell therapy can be safely performed, if the right cell type is used in the right clinical setting. The future of stem cell research will require closer collaborative efforts between scientists and clinicians to understand how cell therapy works and to define the ideal cell type and method of delivery to be able to obtain maximum output.
- Subjects
CARDIOVASCULAR diseases; STEM cells; CARDIAC regeneration; PROGENITOR cells; CELL populations; COMPARATIVE studies
- Publication
International Journal of Pharmacy & Life Sciences, 2013, Vol 4, Issue 2, p2347
- ISSN
0976-7126
- Publication type
Article