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- Title
The Common and Species-Specific Roles of Oviductal Proteins in Mammalian Fertilization and Embryo Development.
- Authors
COY, PILAR; YANAGIMACHI, RYUZO
- Abstract
Proteins are biomolecules responsible for a vast range of functions within living cells and tissues. Over 150 different proteins are present in the fluid of the oviduct, where mammalian oocytes are fertilized and zygotes start to develop. Although fertilization can be achieved in vitro without any contributions from the oviduct or oviductal proteins, some of these proteins play crucial or yet unknown roles in fertilization and embryo development. The inclusion of specific oviductal proteins or purified fractions of oviductal fluids with beneficial effects on gametes, zygotes, or embryos might help to reduce the adverse effects of the periconceptional environment in in vitro-derived embryos and thereby also improve the yield and quality of assisted reproductive technologies (ARTs). The proteins discussed here include osteopontin (SPP1), glycodelin, oviductin (OVGP1), plasmin, heat shock proteins (HSPA8, Grp78, HSP60), lactoferrin, deleted in malignant brain tumors 1 (DMBT1), and fetuin.
- Subjects
FERTILIZATION (Biology); FALLOPIAN tubes; EMBRYOLOGY; REPRODUCTIVE technology; GLYCODELIN; MAMMALS
- Publication
BioScience, 2015, Vol 65, Issue 10, p973
- ISSN
0006-3568
- Publication type
Article
- DOI
10.1093/biosci/biv119