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- Title
Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training.
- Authors
Rios Drummond, Filipe; Bernardes Leite, Luciano; Coutinho de Miranda, Denise; Rios Drummond, Lucas; Neiva Lavorato, Victor; Lopes Soares, Leôncio; Andrade Neves, Clóvis; José Natali, Antônio
- Abstract
Pulmonary arterial hypertension is associated with skeletal muscle myopathy and atrophy and impaired exercise tolerance. Aerobic exercise training has been recommended as a non-pharmacological therapy for deleterious effects imposed by pulmonary arterial hypertension. Aerobic physical training induces skeletal muscle adaptations via reduced inflammation, improved anabolic processes, decreased hypoxia and regulation of mitochondrial function. These benefits improve physical exertion tolerance and quality of life in patients with pulmonary arterial hypertension. However, the mechanisms underlying the therapeutic potential of aerobic exercise to skeletal muscle disfunctions in patients with pulmonary arterial hypertension are not well understood yet. This minireview highlights the pathways involved in skeletal muscle adaptations to aerobic exercise training in patients with pulmonary arterial hypertension.
- Subjects
PULMONARY arterial hypertension; AEROBIC exercises; EXERCISE therapy; SKELETAL muscle; EXERCISE tolerance
- Publication
Frontiers in Physiology, 2023, Vol 14, p1
- ISSN
1664-042X
- Publication type
Article
- DOI
10.3389/fphys.2023.1148146