We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
DESIGN AND SYNTHESIS OF DENSELY FUNCTIONALIZED NOVEL SPIROOXINDOLES AS ANTICANCER AGENTS.
- Authors
Shanmugasundaram, P.; Easwaramoorthy, D.; Mhashal, Anil Ranu; Khan, Ayesha
- Abstract
A series of new Spirooxindole derivatives were designed and synthesized to evaluate their antiproliferative activity by MTT assay. The result revealed most of the compounds exhibited strong antiproliferative properties in comparison with positive control Doxorubicin. Particularly compound 8 showed significant inhibitory activity for both MCF-7 and HeLa cancer cell lines. A molecular docking study was performed to evaluate the potential mechanism of antiproliferative activity. It revealed that designed Spirooxindole derivatives strongly interact with hydrophobic amino acids of the p53 binding site of MDM2. Inhibition of p53-MDM2 interaction results in the reactivation of p53 which is corroborated by the significant antiproliferative activity of the compounds against cancer cell lines. These data signify the potential of designed spirooxindole derivatives as anticancer agents.
- Subjects
ANTINEOPLASTIC agents; HELA cells; MOLECULAR docking; BINDING sites; CELL lines
- Publication
Rasayan Journal of Chemistry, 2023, Vol 16, Issue 3, p1599
- ISSN
0974-1496
- Publication type
Article
- DOI
10.31788/RJC.2023.1638506