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- Title
Enhancing Reactivity and Selectivity of Aryl Bromides: A Complementary Approach to Dibenzo[b,f]azepine Derivatives.
- Authors
Casnati, Alessandra; Fontana, Marco; Coruzzi, Giovanni; Maggi, Raimondo; Maestri, Giovanni; Motti, Elena; Della Ca', Nicola; Aresta, Brunella Maria; Corriero, Nicola
- Abstract
Dihydrodibenzo[b,f]azepines and dibenzo[b,f]azepines can be efficiently synthesized from aryl bromides, o‐bromoanilines and norbornene or norbornadiene by means of palladium catalysis. This protocol gives access to dibenzo[b,f]azepine core containing a variety of electron‐withdrawing substituents on both aromatic rings and complements the previously reported methodology where electron rich aryl iodides were preferentially used. The presence of KI, even in sub‐stoichiometric amount, is crucial for this three‐component reaction. The proper addition of iodide anions has a dramatic effect on reaction rate and selectivity. A formal three‐step synthesis of the tricyclic antidepressant Clomipramine (Anafranil®) is also described. KI‐ck‐start required: Dibenzo[b,f]azepine derivatives can be efficiently synthesized from aryl bromides, o‐bromoanilines and norbornene or norbornadiene by means of palladium catalysis. The presence of KI, even in sub‐stoichiometric amount, is crucial for this three‐component reaction, as it promotes reaction rate and selectivity. A formal three‐step synthesis of the tricyclic antidepressant Clomipramine (Anafranil®) is also described.
- Subjects
ARYL bromides; REACTIVITY (Chemistry); CATALYST selectivity; AZEPINES; PALLADIUM catalysts
- Publication
ChemCatChem, 2018, Vol 10, Issue 19, p4346
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.201800940