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- Title
A Randomized Cross-over Trial of Granisetron and Dexamethasone versus Granisetron Alone: The Role of Dexamethasone on Day 1 in the Control of Cisplatin-induced Delayed Emesis.
- Authors
Sekine, Ikuo; Nishiwaki, Yutaka; Kakinuma, Ryutaro; Kubota, Kaoru; Hojo, Fumihiko; Matsumoto, Taketoshi; Ohmatsu, Hironobu; Yokozaki, Michiya; Kodama, Tetsuro
- Abstract
We studied the role of dexamethasone (DEX) administered on day 1 in controlling cisplatin-induced delayed emesis. Forty patients were randomly allocated to receive either granisetron (GRN) and DEX on day 1, or the same dose of CRN alone. On days 2–5, all the patients received metoclopramide and DEX. They were corssed over to the other antiemetic regimen with their second course of chemotherapy. Thirty-one patients were evaluable for efficacy. The mean visual analogue scale scores for nausea on days 1 and 2 were 9.1 and 18.8 mm for GRN and DEX, and 16.3 and 28.5 mm for GRN alone, respectively (P > 0.05 on day 2). The mean numbers of emetic episodes on days 1–3 were 0.036, 0.46 and 0.36 for GRN and DEX, and 0.39, 0.89 and 0.57 for GRN alone, respectively (P > 0.01 on day 1). Hiccups and restlessness were noted in 38% and 33% of cycles, respectively. Addition of DEX to GRN on day 1 thus enhanced the control of delayed emesis.
- Publication
Japanese Journal of Clinical Oncology, 1996, Vol 26, Issue 3, p164
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/oxfordjournals.jjco.a023201