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- Title
Frequency of Hepatitis B, C and HIV Infections among Transfusion-Dependent Beta Thalassemia Patients in Dhaka.
- Authors
Bhuyan, Golam Sarower; Noor, Aftab Uz Zaman; Sultana, Rosy; Noor, Farjana Akther; Sultana, Nusrat; Sarker, Suprovath Kumar; Islam, Muhammad Tarikul; Sayeed, Md. Abu; Ul Khabir, Md. Imam; Hossain, A. K. M. Ekramul; Zeba, Zebunnesa; Qadri, Syeda Kashfi; Siddique, Md. Ruhul Furkan; Qadri, Syed Saleheen; Qadri, Firdausi; Mannoor, Kaiissar
- Abstract
Transfusion transmitted infections have remained a major deterrent to public health, particularly among the patients with transfusion-dependent Beta thalassemia in developing countries. Although proper donor selection through adoption of WHO-advised infection panel has lowered the rate of infections, the multi-transfused patients are not free of risk. In this study, we screened 148 transfusion-dependent Beta thalassemia patients to determine the frequency of Hepatitis C Virus (HCV), Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV) using the ELISA method. Among them, infected cases with HCV, HBV and HIV were 13.51%, 3.37% and 0%, respectively. Moreover, 2% of the patients were found to be co-infected with both HBV and HCV. The percentage of infections in the patients with frequent transfusion interval (-30 days) was significantly higher (p < 0.0005) than that in the patients with less frequent transfusion intervals (>30 days). Immunochromatography (ICT)-based rapid test kits are usually used to screen and confirm these infections in the blood of the patients. However, ICT-based tests are not sensitive enough to detect the infections. So, a combination of both Nucleic Acid testing (NAT) and serological testing are suggested to significantly reduce the risk of viral infections during blood transfusion.
- Subjects
BETA-Thalassemia; HIV infections; HEPATITIS B; HEPATITIS C virus; HEPATITIS B virus
- Publication
Infectious Disease Reports, 2021, Vol 13, Issue 1, p89
- ISSN
2036-7449
- Publication type
Article
- DOI
10.3390/idr13010011