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- Title
Benign Recurrent Intrahepatic Cholestasis: Where Are We Now?
- Authors
Geladari, Eleni V.; Vallianou, Natalia G.; Margellou, Evangelia; Kounatidis, Dimitris; Sevastianos, Vassilios; Alexopoulou, Alexandra
- Abstract
Benign recurrent intrahepatic cholestasis (BRIC) stands as a rare genetic contributor to cholestasis, aligning itself within the spectrum of inherited intrahepatic cholestasis syndromes, such as progressive familial intrahepatic cholestasis (PFIC) and intrahepatic cholestasis of pregnancy. Manifesting in infancy or early adulthood, BRIC is marked by recurrent episodes of jaundice accompanied by intense pruritus, enduring from weeks to years across the lifespan. Normal gamma-glutamyl transferase (GGT) levels are a characteristic laboratory finding. Initially considered unlikely to progress to chronic liver disease or cirrhosis, some reports suggest BRIC may evolve into a continuous and progressive form of cholestasis. Moreover, these recurrent cholestatic episodes significantly impact quality of life, and certain mutations elevate the risk of hepatobiliary malignancy. Between episodes, histological findings of centrilobular cholestasis and abnormal laboratory parameters revert to normal, potentially obviating the need for liver biopsy. This review focuses on the genetic aspects of BRIC, its pathophysiology, clinical presentation, and prognosis. Additionally, it outlines triggering factors and available treatment options.
- Subjects
CHOLESTASIS; QUALITY of life; HISTOLOGY; LIVER diseases; JAUNDICE
- Publication
Gastroenterology Insights, 2024, Vol 15, Issue 1, p156
- ISSN
2036-7414
- Publication type
Article
- DOI
10.3390/gastroent15010011