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- Title
Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment.
- Authors
Sansone, Stephanie; Widaman, Keith; Hall, Scott; Reiss, Allan; Lightbody, Amy; Kaufmann, Walter; Berry-Kravis, Elizabeth; Lachiewicz, Ave; Brown, Elaine; Hessl, David
- Abstract
Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.
- Subjects
UNITED States; CHI-squared test; CONFIDENCE intervals; FACTOR analysis; FRAGILE X syndrome; MEDICAL cooperation; PSYCHOMETRICS; RELIABILITY (Personality trait); RESEARCH; RESEARCH funding; SCALE analysis (Psychology); STATISTICS; T-test (Statistics); U-statistics; MAXIMUM likelihood statistics; RETROSPECTIVE studies; RESEARCH methodology evaluation; DESCRIPTIVE statistics; THERAPEUTICS
- Publication
Journal of Autism & Developmental Disorders, 2012, Vol 42, Issue 7, p1377
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-011-1370-2