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- Title
Clinical, Angiographic, and Genetic Factors Associated With Early Coronary Stent Thrombosis.
- Authors
Cayla, Guillaume; Hulot, Jean-Sébastien; O'Connor, Stephen A.; Pathak, Atul; Scott, Stuart A.; Gruel, Yves; Silvain, Johanne; Vignalou, Jean-Baptiste; Huerre, Yves; de la Briolle, Axel; Allanic, Frederick; Beygui, Farzin; Barthélémy, Olivier; Montalescot, Gilles; Collet, Jean-Philippe
- Abstract
The article discusses results of a study that examines the association of clinical, angiographic and genetic factors with early coronary stent thrombosis. The study design, setting and subjects are described. The study of 23 genetic variants in 15 different genes showed the significant determinants of early coronary stent thrombosis. Some of the nongenetic independent correlates are acuteness of percutaneous coronary intervention (PCI), complex lesions, left ventricular function less than 40 percent, higher dose of clopidogrel loading and use of proton pump inhibitors. The study has successfully identified the three genes and two clopidogrel-related factors that were associated with early coronary stent thrombosis.
- Subjects
THROMBOSIS; SURGICAL stents; GENES; ANGIOPLASTY; CLOPIDOGREL; PROTON pump inhibitors
- Publication
JAMA: Journal of the American Medical Association, 2011, Vol 306, Issue 16, p1765
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2011.1529