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- Title
Falsely elevated cortisol serum levels in preterm infants due to use of immunoassay.
- Authors
Romijn, Michelle; van de Weijer, Kirsten N.G.; Onland, Wes; Rotteveel, Joost; van Kaam, Anton H.; Heijboer, Annemieke C.; Finken, Martijn J.J.
- Abstract
Keywords: cortisol levels; immunoassay; liquid chromatography-tandem mass spectrometry; preterm infants EN cortisol levels immunoassay liquid chromatography-tandem mass spectrometry preterm infants e206 e209 4 08/22/23 20230901 NES 230901 To the Editor, In the first weeks of life, many preterm infants fail to mount an appropriate cortisol response for the degree of illness or stress, known as relative adrenal insufficiency (RAI) [[1]]. On the x-axis, the cortisol concentrations measured using the LC-MS/MS method and on the y-axis the cortisol concentrations measured using the respective immunoassays are shown. In conclusion, some immunoassays may overestimate serum cortisol levels in preterm infants in their first weeks of life, necessitating the use of a LC-MS/MS method or an immunoassay that has proved to be accurate in preterm infants.
- Subjects
IMMUNOASSAY; PREMATURE infants; HYDROCORTISONE
- Publication
Clinical Chemistry & Laboratory Medicine, 2023, Vol 61, Issue 10, pe206
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2023-0123