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- Title
Early predictors of abnormal MRI patterns in asphyxiated infants: S100B protein urine levels.
- Authors
Bersani, Iliana; Gasparroni, Giorgia; Bashir, Moataza; Aboulgar, Hanna; Mufeed, Hala; Iskander, Iman; Kornacka, Maria; Gruzfeld, Darek; Dotta, Andrea; Campi, Francesca; Longo, Daniela; Savarese, Immacolata; Braguglia, Annabella; Tina, Lucia Gabriella; Nigro, Francesco; Serpero, Laura; Strozzi, Maria Chiara; Maconi, Antonio; Ianniello, Patrizia; Di Battista, Caterina
- Abstract
The early detection and stratification of asphyxiated infants at higher risk for impaired neurodevelopment is challenging. S100B protein is a well-established biomarker of brain damage, but lacks conclusive validation according to the "gold standard" methodology for hypoxic-ischemic encephalopathy (HIE) prognostication, i.e. brain MRI. The aim of the present study was to investigate the predictive role of urinary S100B concentrations, assessed in a cohort of HIE infants receiving therapeutic hypothermia (TH), compared to brain MRI. Assessment of urine S100B concentrations was performed by immunoluminometric assay at first void and at 4, 8, 12, 16, 20, 24, 48, 72, 96, 108 and 120-h after birth. Neurologic evaluation, routine laboratory parameters, amplitude-integrated electroencephalography, and cerebral ultrasound were performed according to standard protocols. Brain MRI was performed at 7–10 days of life. Overall, 74 HIE neonates receiving TH were included in the study. S100B correlated, already at first void, with the MRI patterns with higher concentrations in infants with the most severe MRI lesions. High S100B urine levels soon after birth constitute trustable predictors of brain injury as confirmed by MRI. Results support the reliability of S100B in clinical daily practice and open the way to its inclusion in the panel of parameters used for the selection of cases suitable for TH treatment.
- Subjects
MAGNETIC resonance imaging; INFANTS; CEREBRAL anoxia-ischemia; THERAPEUTIC hypothermia; BRAIN damage
- Publication
Clinical Chemistry & Laboratory Medicine, 2022, Vol 60, Issue 11, p1745
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2022-0559