We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Multigenomic Delineation of Plasmodium Species of the Laverania Subgenus Infecting Wild-Living Chimpanzees and Gorillas.
- Authors
Weimin Liu; Sundararaman, Sesh A.; Loy, Dorothy E.; Learn, Gerald H.; Yingying Li; Plenderleith, Lindsey J.; Ndjango, Jean-Bosco N.; Speede, Sheri; Atencia, Rebeca; Cox, Debby; Shaw, George M.; Ayouba, Ahidjo; Peeters, Martine; Rayner, Julian C.; Hahn, Beatrice H.; Sharp, Paul M.
- Abstract
Plasmodium falciparum, the major cause of malaria morbidity and mortality worldwide, is only distantly related to other human malaria parasites and has thus been placed in a separate subgenus, termed Laverania. Parasites morphologically similar to P. falciparumhavebeen identified inAfricanapes,but only one other Laverania species, Plasmodium reichenowi from chimpanzees,has been formally described. Although recent studies have pointed to the existence of additional Laverania species, their precise number and host associations remain uncertain, primarily because of limited sampling and a paucity of parasite sequences other than from mitochondrial DNA. To address this, we used limiting dilution polymerase chain reaction to amplify additional parasite sequences from a large number of chimpanzee and gorilla blood and fecal samples collected at two sanctuaries and 30 field sites across equatorial Africa. Phylogenetic analyses ofmore than 2,000 new sequences derived fromthemitochondrial, nuclear, and apicoplast genomes revealed six divergent and well-supported clades within the Laverania parasite group. Although two of these clades exhibited deep subdivisions in phylogenies estimated fromorganelle gene sequences, these sublineages were geographically defined and not present in trees from four unlinked nuclear loci. This greatly expanded sequence data set thus confirms six, and not seven or more, ape Laverania species, of which P. reichenowi, Plasmodium gaboni, and Plasmodium billcollinsi only infect chimpanzees, whereas Plasmodium praefalciparum, Plasmodium adleri,andPladmodium blacklocki only infect gorillas. Thenewsequence data also confirm the P. praefalciparum origin of human P. falciparum.
- Subjects
PLASMODIUM falciparum; MALARIA; PARASITES; NUCLEOTIDE sequencing; MITOCHONDRIAL DNA
- Publication
Genome Biology & Evolution, 2016, Vol 8, Issue 6, p1929
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evw128