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- Title
Experimentally Induced Hyperlipidemia and Associated Atherosclerosis in the Aorta and Vascular Expression of CD 31, CD44, Beta-catenin and E Cadherin in Wistar Male Rats.
- Authors
Naik, H. Srinivasa; Srilatha, Ch.; Sujatha, K.; Sreedevi, B.; TNVKV, Prasad
- Abstract
Background: Hyperlipidemia is the disorder of lipid metabolism, characterized by elevated serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoproteins cholesterol (VLDL-C) and decreased high-density lipoprotein cholesterol (HDL-C). Atherosclerosis is a cardiovascular and fibroproliferative inflammatory disease commonly associated with dyslipidemia. Methods: The study was conducted using 24 Wistar male rats, divided into two groups of 12 rats each. Hyperlipidemia and atherosclerosis were induced by the addition of 1% cholesterol and 15% saturated oil to the 1000 g of standard rat diet and given to group II rats. Group I kept as control and maintained for 90 days. Result: The present experiment established hyperlipidemia with a significant increase of TC, TG, LDL-C and decreased HDL-C cholesterol with initiated atherosclerotic lesions in the aorta and showed varying degrees of positivity with CD31, CD44, Cadherin and Beta-catenin proteins.
- Subjects
LDL cholesterol; HDL cholesterol; LABORATORY rats; AORTA; HYPERLIPIDEMIA; CD44 antigen; CADHERINS
- Publication
Indian Journal of Animal Research, 2022, Vol 56, Issue 9, p1144
- ISSN
0367-6722
- Publication type
Article
- DOI
10.18805/IJAR.B-4209