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- Title
B-Lymphoblastic Leukemia/Lymphoma Associated with t(8;13)(p11;q12)/ZMYM2 (ZNF198)-FGFR1: Rare Case and Review of the Literature.
- Authors
Trimaldi, Janese; Carballido, Estrella M.; Bowers, Jeremy W.; anguiano, arturo L.; Zhang, Zhong J.; Shah, Bijal D.; Bruno, Salvador; List, alan F.; Moscinski, Lynn C.; Grady, Terrence; agosti, Steven J.; Kang, Loveleen; Zhang, Ling
- Abstract
Myeloid and lymphoid neoplasms with fibroblastic growth factor receptor-1 (FGFR1) abnormalities originate from mutated pluripotent stem cells and have a heterogeneous clinical presentation. There are 12 identified partner genes commonly involved in FGFR1 translocation at an 8p11 breakpoint. In FGFR1-related neoplasms, T-lymphoblastic lymphoma with eosinophilia is the most common clinical scenario, whereas acute B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is rare. To date, only 7 cases of B-ALL/LBL with FGFR1 abnormalities have been reported. Here, we report an additional case of a 64-year-old gentleman with leukocytosis, eosinophilia and diffuse mediastinal and general lymphadenopathy. Bone marrow examination showed patchy infiltrates of immature precursors/blasts, along with myeloid/eosinophilic hyperplasia. Immunophenotyping confirmed increased B lymphoblasts (30-40%). Karyotyping revealed cytogenetic abnormalities, including t(8;13)(p11;q12)/ZMYM2 (ZNF198)-FGFR1 and trisomy 21. The patient did not respond to hyper-CVAD chemotherapy and within 4 months developed acute myelomonocytic leukemia and expired 11 months after the initial diagnosis. Similar cases from the literature are reviewed. Copyright © 2013 S. Karger AG, Basel
- Subjects
BONE marrow diseases; LYMPHOID tissue; PLURIPOTENT stem cells; LEUCOCYTOSIS; EOSINOPHILIA; IMMUNOPHENOTYPING; PATIENTS; CANCER
- Publication
Acta Haematologica, 2013, Vol 130, Issue 3, p127
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000347030