We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Vitamin B<sub>12</sub>-Responsive Pancytopenia Mimicking Myelodysplastic Syndrome.
- Authors
Myungshin Kim; Sung-Eun Lee; Joonhong Park; Jihyang Lim; Byung-Sik Cho; Yoo-Jin Kim; Hee-Je Kim; Seok Lee; Chang-Ki Min; Yonggoo Kim; Seok-Goo Cho
- Abstract
This study presents 12 patients (7 women and 5 men) with vitamin B12-responsive pancytopenia who had discordant laboratory findings and were misdiagnosed as having myelodysplastic syndrome (MDS). The median hemoglobin level was 6.5 g/dl, and the leukocyte and platelet counts were 2.85 × 109/l and 55.5 × 109/l, respectively. The median serum lactate dehydrogenase level was high (3,204.5 IU/l). The serum vitamin B12 levels were within normal limits at the initial evaluation, but a serial follow-up of the vitamin B12 levels revealed either fluctuations or a gradual decrease. The patients were initially diagnosed with MDS and responded rapidly to a 7-day parenteral B12 treatment with normal complete blood counts (CBCs). We propose that patients suspected to have MDS may suffer from vitamin B12 deficiency and that this can be revealed by a normalization of CBCs following 7 days of treatment with parental vitamin B12. Copyright © 2011 S. Karger AG, Basel
- Subjects
VITAMIN B12; DIAGNOSTIC errors; MYELODYSPLASTIC syndromes; HEMOGLOBINS; LEUCOCYTES
- Publication
Acta Haematologica, 2011, Vol 125, Issue 4, p198
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000322941