We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Avaliações funcionais e morfométrica de modelo de lesão muscular por agulha de biópsia em gastrocnêmio de ratos.
- Authors
Bruning, Maria Cecília Ribeiro; demila de Freitas Tavares, Alana Lu; de Lima, Aline Daiane; Costa, Juliana Roncini Gomes da; de Fátima Chasko Ribeiro, Lucinéia; Brancalhão, Meire Costa; Pertille, Adriana; Bertolini, Gladson Ricardo Flor
- Abstract
Introduction: Among the experimental models, the use of a biopsy needle was shown to be effective to reproduce lesions that occur with athletes. Objective: To evaluate the grip strength, nociception and morphological alterations of the gastrocnemius muscle of animals submitted to muscle injury. Methods: Six Wistar rats were used. The lesion was performed at the myotendinous junction of the right gastrocnemius muscle using a biopsy needle. For functional evaluation, the grip strength test and nociceptive evaluation were used at three moments: 24 hours before the injury (AV1); on the second postoperative day (AV2) and on the sixth postoperative day (AV3). At the end of the experiment the muscle was removed for morphological analysis. Results: There was a reduction in grip strength between AV1 and AV2 (p = 0.0031). For the nociception the values of AV2 (p < 0.001) and AV3 (p = 0.0109) were higher than AV1. In the muscle fibers region, there was disarrangement of the fascicular pattern, increased blood vessel size, the amount of connective tissue, fibroblasts and inflammatory cells. Conclusion: Muscle lesion by biopsy needle caused reduction of grip strength and nociception of the damaged limb, as well as the characteristic stages of the muscular degeneration process and the beginning of the regeneration process.
- Subjects
SKELETAL muscle; SKELETAL muscle injuries; ANIMAL experimentation; BIOLOGICAL models; BLOOD vessels; CONNECTIVE tissues; FIBROBLASTS; GRIP strength; LIFE skills; NEEDLE biopsy; POSTOPERATIVE period; RATS; CALF muscles; DESCRIPTIVE statistics; NOCICEPTIVE pain; ANATOMY
- Publication
Fisioterapia Brasil, 2018, Vol 19, Issue 6, p768
- ISSN
1518-9740
- Publication type
Article
- DOI
10.33233/fb.v19i6.2286