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- Title
Proteins of Bartonella bacilliformis: Candidates for Vaccine Development.
- Authors
Henriquez-Camacho, Cesar; Ventosilla, Palmira; Minnick, Michael F.; Ruiz, Joaquim; Maguiña, Ciro
- Abstract
Bartonella bacilliformis is the etiologic agent of Carrión’s disease or Oroya fever. B. bacilliformis infection represents an interesting model of human host specificity. The notable differences in clinical presentations of Carrión’s disease suggest complex adaptations by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins. This review focuses on proteins involved in interactions between B. bacilliformis and the human host. Some of them (e.g., flagellin, Brps, IalB, FtsZ, Hbp/Pap31, and other outer membrane proteins) are potential protein antigen candidates for a synthetic vaccine.
- Subjects
VERRUGA peruana; SYNTHETIC vaccines; BACTERIAL proteins; BARTONELLA; BACTERIAL adaptation; HOST specificity (Biology)
- Publication
International Journal of Peptides, 2015, Vol 2015, p1
- ISSN
1687-9767
- Publication type
Article
- DOI
10.1155/2015/702784