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- Title
Anti-oxidant, DNA-damage protection and anti-cancer properties of n-butanol extract of the endemic Perralderia coronopifolia.
- Authors
Bekhouche, Khadidja; Ozen, Tevfik; Boussaha, Sara; Koldas, Serkan; Yenigun, Semiha; Lassed, Somia; Demirtas, Ibrahim; Benayache, Fadila; Benayache, Samir; Zama, Djamila
- Abstract
This study was designed to evaluate in vitro the total phenolic, flavonoid content, anti-oxidant activity, oxidative DNA-damage protection and anticancer activity of n-butanol extract from Perralderia coronopifolia, endemic plant. DNA protection capacity was performed using 46966 plasmid DNA against UV-photolysis of H2O2-induced oxidative damage. The anti-proliferative effects of extract were performed on HeLa and C6 cells. Experimental results showed that extract had convenient number of phenolic and flavonoids. Furthermore, it provided strong anti-oxidant, reducing power, hydrogen peroxide and higher DPPH scavenging ability with IC50= 7.02 ± 0.02 μg/mL. As it shown an oxidative plasmid DNA-damage inhibition against UV-photolysis of H2O2, an anti-cancer activity at higher concentrations in cells. The data obtained that P. coronopifolia extract could be useful in human protection against infection and degenerative illness.
- Subjects
ANGIOSPERMS; THERAPEUTIC use of plant extracts; DNA damage; ANTIOXIDANTS; ANTINEOPLASTIC agents; THERAPEUTICS
- Publication
Bangladesh Journal of Pharmacology, 2018, Vol 13, Issue 1, p82
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v13i1.34255