We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Arabinosyl transferase inhibitor design against Mycobacterium tuberculosis using ligand based drug design approach.
- Authors
Kolita, Bhaskor; Gogoi, Dhrubajyoti; Dutta, Partha Pratim; Bordoloi, Manobjyoti; Bezbaruah, Rajib Lochan
- Abstract
Antibiotic resistance is a major challenge to combat tuberculosis. Several reports of antibiotic resistance strains of Mycobacterium tuberculosis is strongly demanding the need of new and alternative antibiotics for its inhibition. Therefore, current investigation is an attempt to screen few lead molecules for the inhibition of arbinosyl transferase enzyme of M. tuberculosis. The inhibition of this enzyme is an established target of many antibiotics especially ethambutol. Herein, we have considered the structure of ethambutol as a starting point to screen active compound then ethambutol. Similar compounds were searched in chemical database and six compounds were identified and considered as selective arbinosyl transferase inhibitor based on physiochemical properties, bioactivity and ADME with least docking score. The compounds viz. ZINC00388344, ZINC003884, Chemspider2057082, ZINC- 00388344, ZINC0038846, Chemspider2057082, Etha17 (analog) and Etha10 (analog) were finally screened and recommended for in vitro investigation.
- Subjects
TRANSFERASES; ENZYME inhibitors; DRUG design; ANTIBIOTICS; MYCOBACTERIUM tuberculosis; LIGANDS (Biochemistry); DRUG resistance in bacteria
- Publication
Bangladesh Journal of Pharmacology, 2014, Vol 9, Issue 2, p225
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v9i2.18270