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- Title
Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid.
- Authors
Ali, Saqib; Igoli, John; Clements, Carol; Semaan, Dima; Alamzeb, Muhammad; Mamoon-Ur-Rashid; Shah, Syed Qaisar; Ferro, Valerie A.; Gray, Alexander I.; Khan, M. Rafiullah
- Abstract
Methanol extracts of the roots of B. brevissima and B. parkeriana were examined for antidiabetic and antimicrobial activities. Six compounds i.e berberine, 8- oxo-berberine, dehydrocheilanthifoline, columbamine, jatrorrhizine and glutamic acid were isolated from the active fractions of these species for the first time. The antidiabetic activity was determined against Protein Tyrosine Phosphatase 1B (PTP 1B), a negative insulin regulator while the antimicrobial activity was performed against four bacterial strains: Mycobacterium marinum ATCC BAA535, sporadic Methicillin Resistant Staphylococcus aureus (SMRSA), endemic Methicillin Resistant Staphylococcus aureus (EMRSA) and Escherichia coli ATCC.8739 at different concentrations. Amongst the isolated compounds 8-oxo-berberine was found to be the most active antidiabetic (29 % of the positive control) while jatrorrhizine was the most active and selective antimicrobial against SMRSA and EMRSA (-1.2 % of the DMSO (D) control).
- Subjects
HYPOGLYCEMIC agents; ANTI-infective agents; BARBERRIES; METHANOL; INSULIN regulation; GLUTAMIC acid; THERAPEUTICS
- Publication
Bangladesh Journal of Pharmacology, 2013, Vol 8, Issue 3, p336
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v8i3.13888