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- Title
Serum Amyloid A Levels Associated with Gastrointestinal Manifestations in Henoch-Schönlein Purpura.
- Authors
He, Xuelian; Zhao, Yulan; Li, Yin; Kang, Shixiu; Ding, Yan; Luan, Jiangwei; Zhao, Peiwei; Liu, Ningsheng; Yin, Wei
- Abstract
Henoch-Schönlein purpura (HSP) is considered as an immune-mediated inflammatory disease. Serum amyloid A (SAA) is an acute-phase protein with proinflammatory effects. We investigated the levels of SAA in HSP patients and examined whether SAA levels are associated with organ involvement and disease severity. Seventy patients with HSP, including 35 with nephritis (HSPN) and 35 without HSPN, and 20 controls were recruited in our study. SAA levels were measured and other clinical laboratory parameters, including C-reactive protein, erythrocyte sedimentation rate, complement 3 (C3), C4, and immunoglobulin (Ig) A, were recorded. SAA levels were not found to be independently associated with renal, joint involvement, and disease severity. However, higher SAA levels were observed in HSP patients with gastrointestinal (GI) manifestations ( p = 0.006, p = 0.048). Moreover, the levels of SAA were significantly associated with duration of disease ( p < 0.005, p < 0.04). Our findings suggested that SAA was significantly associated with disease duration and GI manifestations in HSP patients.
- Subjects
ACUTE phase proteins; IMMUNOGLOBULIN A; C-reactive protein; NEPHRITIS; SCHOENLEIN-Henoch purpura; GASTROINTESTINAL system
- Publication
Inflammation, 2012, Vol 35, Issue 4, p1251
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-012-9435-8