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- Title
Host stress hormone norepinephrine reduces in vitro activity of aminoglycoside against carbapenemase-producing Enterobacterales.
- Authors
Inaba, Masato; Doi, Yohei
- Abstract
This article discusses the impact of the stress hormone norepinephrine (NE) on the activity of antibiotics against carbapenemase-producing Enterobacterales (CPE), a highly drug-resistant pathogen. The study found that NE enhances biofilm formation and reduces the effectiveness of aminoglycoside antibiotics against CPE. These findings suggest that elevated NE levels in severely ill patients may compromise the efficacy of antibiotic therapy for CPE infections, even when the infecting strain appears susceptible based on standard susceptibility testing. The study highlights the importance of considering physiological stress responses in the management of drug-resistant infections.
- Subjects
NORADRENALINE; HORMONES; GRAM-negative bacteria; ABDOMINAL aortic aneurysms; ADRENALINE
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2024, Vol 79, Issue 6, p1468
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkae113