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- Title
Atriyal natriüretik peptid infüzyonunun izole sıçan kalbinde iskemi sonrası oluşturduğu hemodinamik değişikliklerde egzersizin rolü.
- Authors
Vardar, Selma Arzu; Palabıyık, Orkide; Yalta, Tülin; Özen, Serap Topçu; Guksu, Zuhal; Topuz, Ruhan; Karadağ, Çetin Hakan
- Abstract
Objectives: The effect of atrial natriuretic peptide (ANP) infusion on left ventricle hemodynamic responses following low flow ischemia and the role of exercise in this effect were investigated in this study. Material and methods: All rats were applied low flow ischemia during 60 minutes and reperfusion during 120 minutes. Ischemia and reperfusion were applied for Exercise (E) groups throughout five consecutive days following Walking exercise. Two groups which were applied 0.1 µM/L ANP at the first 15 minutes of exercise constituted ANP (n=6) and Exercise-ANP (n=6) groups. Left ventricle developed pressure (LVDP), maximum-minimum rates of change in left ventricular pressure (+dP/dtmax and -dP/dt) were recorded in all groups. Results: When SVGB, +dp/dt, -dp/ dt and heart rate values of LVDP, dP/dtmax and dP/dtmin were compared before ischemia and after at 1st, 60th and 120th minutes of reperfusion a statistically significant difference was not observed among groups. Similarly, when percent values of infarct areas were compared a statistically significant difference was not found among four groups. Conclusion: Short duration and intense exercise may not affect the alterations occurred at cardiac contractility resulted from ANP application in reperfusion period.
- Publication
Journal of General Medicine / Genel Tıp Dergisi, 2015, Vol 25, Issue 2, p40
- ISSN
1301-191X
- Publication type
Article