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- Title
Maternal intrapartum antibiotic treatment continues to exert a bactericidal effect on the umbilical cord and peripheral venous blood of newborn infants.
- Authors
Hershkovich–Shporen, C; Bardenstein, R; Blickstein, I; Shinwell, E S; Flidel‐Rimon, O
- Abstract
<bold>Aim: </bold>It is unclear whether maternal intrapartum antibiotic treatment (IAT) continues to exert a bactericidal effect on common pathogens in neonates. We studied the in vitro bactericidal effect of IAT on the cord and peripheral venous blood of newborn infants.<bold>Methods: </bold>Umbilical cord and peripheral venous blood from newborn infants born at Kaplan Medical Center, Israel, from April to October 2014 were studied for serum bactericidal titres against Group B Streptococcus (GBS) and Escherichia coli (E. coli) strains. We studied 60 samples of umbilical cord blood and 18 samples of peripheral venous blood from 60 newborn infants whose mothers received IAT. The controls were 10 samples of cord blood from mothers without IAT.<bold>Results: </bold>Cord blood exerted a bactericidal effect against 98% of GBS isolates but only 8% of E.coli isolates. Peripheral blood exerted a bactericidal effect against GBS in 94% of cases, but not against E. coli. No bactericidal effect was seen in the blood from the controls.<bold>Conclusion: </bold>We found a continued bactericidal effect of umbilical cord blood and neonatal peripheral blood from newborn infants of IAT-treated mothers, mainly against GBS, but rarely against E. Coli. These findings may assist clinicians treating at-risk infants exposed to IAT.
- Subjects
TREATMENT of escherichia coli diseases; ANTIBIOTICS; INTRAPARTUM care; NEWBORN infant health; UMBILICAL cord; STREPTOCOCCUS agalactiae; BACTERICIDES; CORD blood; PHYSIOLOGY; PREVENTION
- Publication
Acta Paediatrica, 2017, Vol 106, Issue 11, p1767
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.13982