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- Title
Specificity and disease in the ubiquitin system.
- Authors
Chaugule, Viduth K.; Walden, Helen
- Abstract
Post-translationalmodification (PTM) of proteins by ubiquitination is an essential cellular regulatory process. Such regulation drives the cell cycle and cell division, signalling and secretory pathways, DNA replication and repair processes and protein quality control and degradation pathways. A huge range of ubiquitin signals can be generated depending on the specificity and catalytic activity of the enzymes required for attachment of ubiquitin to a given target. As a consequence of its importance to eukaryotic life, dysfunction in the ubiquitin system leads to many disease states, including cancers and neurodegeneration. This review takes a retrospective look at our progress in understanding the molecular mechanisms that govern the specificity of ubiquitin conjugation.
- Subjects
UBIQUITIN; CHEMICAL modification of proteins; POST-translational modification; DNA replication; CELLULAR control mechanisms; CELL cycle
- Publication
Biochemical Society Transactions, 2016, Vol 44, Issue 1, p212
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20150209