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- Title
Extensive Mycobacterium tuberculosis circulation in a highly endemic prison and the need for urgent environmental interventions.
- Authors
SÁNCHEZ, A.; HUBER, F. D.; MASSARI, V.; BARRETO, A.; CAMACHO, L. A. B.; CESCONI, V.; SAAD, M. H.; LAROUZE, B.
- Abstract
Aimed at assessing the circulation of Mycobacterium tuberculosis in a highly endemic prison, this 13-month prospective study was performed on strains isolated from tuberculosis (TB) cases detected passively and actively. We used X-ray screening of newly admitted inmates and mass screening at the beginning of the study and again 1 year later. Of the 94 strains genotyped by restriction fragment-length polymorphism, 79 (84·0%) belonged to one of the 12 identified clusters (2–21 strains each), including two main clusters (18 and 21 cases, respectively). A history of TB treatment was reported in 22/79 (27·8%) clustered cases. Time–space distribution of clustered cases was predominantly consistent with transmission, in micro-epidemics. Given the dominant pattern of exogenous infection and the extensive strain circulation, effective TB control should emphasize reduction of overcrowding and improvement of environmental measures as a complement to detection and treatment of cases.
- Subjects
MYCOBACTERIUM tuberculosis; MOLECULAR epidemiology; RESTRICTION fragment length polymorphisms; X-rays; LONGITUDINAL method; GENETIC polymorphisms; MEDICAL screening; THERAPEUTICS
- Publication
Epidemiology & Infection, 2012, Vol 140, Issue 10, p1853
- ISSN
0950-2688
- Publication type
Article
- DOI
10.1017/S0950268811002536