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- Title
Malignant Myopericytoma-like Tumor in a Fischer Rat.
- Authors
TAKAHASHI, NAOFUMI; YOSHIDA, TOSHINORI; TAKEUCHI, YUKIKO; KUWAHARA, MAKI; NAKASHIMA, NOBUAKI; CHIBA, YUKO; HARADA, TAKANORI
- Abstract
Myopericytoma is a perivascular tumor that has been recently described in humans, but not in laboratory rodents. The authors encountered an intra-abdominal tumor resembling human malignant myopericytoma in a Fischer rat. Grossly, the tumor was found as two brown-colored masses located in the mesentery of rectum. Microscopically, the tumor was composed of oval to spindle-shaped cells, which were arranged in sheets around numerous thin-walled branching vessels and partly showed a concentric perivascular growth pattern. Mitoses were frequently seen, and the tumor cells showed a local invasion. Immunohistochemically, the tumor cells were strongly positive for alpha-smooth muscle actin and weakly positive for vimentin and desmin. Ultrastructurally, the tumor cells had dendritic processes, actin-like thin filaments with dense bodies, basement membranes, hemidesmosomes, and micropinocytotic vesicles. These findings suggest that the most appropriate term for diagnosis of the present case could be a malignant myopericytoma.
- Subjects
CANCER; TUMORS; LABORATORY mice; MESENTERY; EPITHELIAL cells; BIOLOGICAL membranes
- Publication
Toxicologic Pathology, 2008, Vol 36, Issue 5, p738
- ISSN
0192-6233
- Publication type
Article
- DOI
10.1177/0192623308320804