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- Title
Effects of Chinese yam storage protein on formation of aberrant crypt foci in 1,2-dimethylhydrazine-treated mice.
- Authors
KATSUHITO ARAI; TAMIKO YAMAZAKI; YOSHIHIKO TOKUJI; MIKA KAWAHARA; KIYOSHI OHBA; KAZUNORI HIRONAKA; MIKIO KINOSHITA; MASAO OHNISHI
- Abstract
The effects of Chinese yam (Dioscorea opposita Thunb.) dietary storage protein on the formation of 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) were investigated in large intestines of mice. Feeding with Chinese yam storage protein resulted in significant suppression of DMH-induced ACF formation in all mice examined. Dietary yam and yam storage protein suppressed aberrant crypt (AC) growth and significantly increased terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) positive cell numbers in large intestines. An in vitro study showed that the digestion products of yam storage protein induced cellular apoptosis. In agreement with this finding, the present study also clearly demonstrated that DMH-induced ACF formation was inhibited by dietary yams. Hence, daily ingestion of yams may suppress colon carcinomas in humans.
- Subjects
DIOSCOREA batatas; ABERRANT crypt foci; FOOD storage; DIMETHYLHYDRAZINES; COLON cancer treatment; LABORATORY mice
- Publication
Journal of Food & Nutrition Research, 2013, Vol 52, Issue 3, p139
- ISSN
1336-8672
- Publication type
Article