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- Title
Segmental Intestinal Absorption of Ranitidine: Investigative and Therapeutic Implications.
- Authors
Ilalpern, Neil A.; Colucci, Robert D.; Turk, Jonathan; Freed, Jeffrey S.; McElhinney, A. J.; Bishop, Allen; Greenstein, Robert
- Abstract
The absorption of ranitidine from different segments of the intestinal tract was studied in a subject who bad an anatomically divided small intestine. The results indicate that the drug is maximally absorbed from the small bowel rather than the stomach. Subsequent animal studies have shown that absorption of ranitidine in dogs is primarily duodenal followed by jejunal and ileal. The lack of gastric absorption, with predominantly small bowel absorption, may have investigational and therapeutic implications in a variety of gastrointestinal diseases.
- Subjects
INTESTINAL absorption; RANITIDINE; THERAPEUTICS; INTESTINES; DUODENUM; GASTRIC diseases
- Publication
American Journal of Gastroenterology (Springer Nature), 1990, Vol 85, Issue 5, p539
- ISSN
0002-9270
- Publication type
Article