We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Short-Term Caloric Restriction Induces Accumulation of Myocardial Triglycerides and Decreases Left Ventricular Diastolic Function in Healthy Subjects.
- Authors
van der Meer, Rutger W.; Hammer, Sebastiaan; Smit, Johannes W. A.; Frölich, Marijke; Bax, Jeroen J.; Diamant, Michaela; Rijzewijk, Luuk J.; de Roos, Albert; Romijn, Johannes A.; Lamb, Hildo J.
- Abstract
OBJECTIVE--Diabetes and obesity are associated with increased plasma nonesterified fatty acid (NEFA) levels, myocardial triglyceride accumulation, and myocardial dysfunction. Because a very low-calorie diet (VLCD) also increases plasma NEFA levels, we studied the effect of a VLCD on myocardial triglyceride content and cardiac function in healthy subjects. RESEARCH DESIGN AND METHODS--Fourteen healthy nonobese men underwent 1H-magnetic resonance spectroscopy IMRS) to determine myocardial and hepatic triglyceride content, 31P-MRS to assess myocardial high-energy phosphate (HEP) metabolism (phosphocreatine/ATP), and magnetic resonance imaging of myocardial function at baseline and after a 3-day VLCD. RESULTS--After the dietary intervention, plasma NEFA levels increased compared with those at baseline (from 0.5 ± 0.1 to 1.1 ± 0.1 mmol/l, P < 0.05). Concomitantly, myocardial triglyceride content increased by ∼55% compared with that at baseline (from 0.38 ± 0.05 to 0.59 ± 0.06%, P < 0.05), whereas liver triglyceride content decreased by ∼32% (from 2.2 ± 0.5 to 1.5 ± 0.4%, P < 0.05). The VLCD did not change myocardial phosphocreatine-to-ATP ratio (2.33 ± 0.15 vs. 2.33 ± 0.08, P > 0.05) or systolic function. Interestingly, deceleration of the early diastolic flow across the mitral valve decreased after the VLCD (from 3.37 ± 0.20 to 2.91 ± 0.10 ml/s2 x 10-3, P < 0.05). This decrease in diastolic function was significantly correlated with the increase in myocardial triglyceride content. CONCLUSIONS--Short-term VLCD induces accumulation of myocardial triglycerides. In addition, VLCD decreases left ventricular diastolic function, without alterations in myocardial HEP metabolism. This study documents diet-dependent physiological variations in myocardial triglyceride content and diastolic function in healthy subjects. Diabetes 56:2849-2853, 2007
- Subjects
VERY low-calorie diet; TRIGLYCERIDES; MYOCARDIUM; DIABETES; OBESITY; FATTY acids
- Publication
Diabetes, 2007, Vol 56, Issue 12, p2849
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/db07-0768