We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and Evaluation on the Fungicidal Activity of S-Alkyl Substituted Thioglycolurils.
- Authors
Vinogradova, Ekaterina E.; Alekseenko, Anna L.; Popkov, Sergey V.; Kolotyrkina, Natalya G.; Kravchenko, Angelina N.; Gazieva, Galina A.
- Abstract
A series of S-alkyl substituted thioglycolurils was prepared through the alkylation of corresponding thioglycolurils with halogenoalkanes and tested for their fungicidal activity against six phytopathogenic fungi from different taxonomic classes: Venturia inaequalis, Rhizoctonia solani, Fusarium oxysporum, Fusarium moniliforme, Bipolaris sorokiniana, and Sclerotinia sclerotiorum, and two pathogenic yeasts: Candida albicans and Cryptococcus neoformans var. grubii. A number of S-alkyl substituted thioglycolurils exhibited high activity against Venturia inaequalis and Rhizoctonia solani (85–100% mycelium growth inhibition), and moderate activity against other phytopathogens. S-Ethyl substituted thioglycolurils possessed a high activity against Candida albicans. Additionally, the hemolytic and cytotoxic properties of promising derivatives were determined using human red blood cells and human embryonic kidney cells, respectively. Two S-ethyl derivatives possessed both low cytotoxicity against normal human cells and high fungicidal activity against Candida albicans.
- Subjects
CANDIDA albicans; RHIZOCTONIA solani; SCLEROTINIA sclerotiorum; PHYTOPATHOGENIC fungi; ERYTHROCYTES; CRYPTOCOCCUS neoformans; FUSARIUM oxysporum; FUNGICIDES
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 6, p5756
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24065756