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- Title
Protein Kinase CK2 Contributes to Glucose Homeostasis by Targeting Fructose-1,6-Bisphosphatase 1.
- Authors
Pack, Mandy; Gulde, Tim Nikolai; Völcker, Michelle Victoria; Boewe, Anne S.; Wrublewsky, Selina; Ampofo, Emmanuel; Montenarh, Mathias; Götz, Claudia
- Abstract
Glucose homeostasis is of critical importance for the survival of organisms. It is under hormonal control and often coordinated by the action of kinases and phosphatases. We have previously shown that CK2 regulates insulin production and secretion in pancreatic β-cells. In order to shed more light on the CK2-regulated network of glucose homeostasis, in the present study, a qRT-PCR array was carried out with 84 diabetes-associated genes. After inhibition of CK2, fructose-1,6-bisphosphatase 1 (FBP1) showed a significant lower gene expression. Moreover, FBP1 activity was down-regulated. Being a central enzyme of gluconeogenesis, the secretion of glucose was decreased as well. Thus, FBP1 is a new factor in the CK2-regulated network implicated in carbohydrate metabolism control.
- Subjects
PROTEIN kinase CK2; HOMEOSTASIS; GLUCOSE; CARBOHYDRATE metabolism; METABOLIC regulation; INSULIN
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 1, p428
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24010428