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- Title
Fe 3 O 4 Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in D-Galactose-Induced Aged Mice.
- Authors
Xia, Zihao; Gao, Manman; Sheng, Peng; Shen, Mengmeng; Zhao, Lin; Gao, Lizeng; Yan, Bingchun
- Abstract
Aging is a process associated with blood–brain barrier (BBB) damage and the reduction in neurogenesis, and is the greatest known risk factor for neurodegenerative disorders. However, the effects of Fe3O4 nanozymes on neurogenesis have rarely been studied. This study examined the effects of Fe3O4 nanozymes on neuronal differentiation in the dentate gyrus (DG) and BBB integrity of D-galactose-induced aged mice. Long-term treatment with Fe3O4 nanozymes (10 μg/mL diluted in ddH2O daily) markedly increased the doublecortin (DCX) immunoreactivity and decreased BBB injury induced by D-galactose treatment. In addition, the decreases in the levels of antioxidant proteins including superoxide dismutase (SOD) and catalase as well as autophagy-related proteins such as Becin-1, LC3II/I, and Atg7 induced by D-galactose treatment were significantly ameliorated by Fe3O4 nanozymes in the DG of the mouse hippocampus. Furthermore, Fe3O4 nanozyme treatment showed an inhibitory effect against apoptosis in the hippocampus. In conclusion, Fe3O4 nanozymes can relieve neuroblast damage and promote neuroblast differentiation in the hippocampal DG by regulating oxidative stress, apoptosis, and autophagy.
- Subjects
IRON oxides; DENTATE gyrus; SYNTHETIC enzymes; BLOOD-brain barrier; HIPPOCAMPUS (Brain); NEURONAL differentiation
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 12, p6463
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23126463