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- Title
DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat.
- Authors
Boughey, Harvey; Jurga, Mateusz; El-Khamisy, Sherif F.
- Abstract
As we age, our bodies accrue damage in the form of DNA mutations. These mutations lead to the generation of sub-optimal proteins, resulting in inadequate cellular homeostasis and senescence. The build-up of senescent cells negatively affects the local cellular micro-environment and drives ageing associated disease, including neurodegeneration. Therefore, limiting the accumulation of DNA damage is essential for healthy neuronal populations. The naked mole rats (NMR) are from eastern Africa and can live for over three decades in chronically hypoxic environments. Despite their long lifespan, NMRs show little to no biological decline, neurodegeneration, or senescence. Here, we discuss molecular pathways and adaptations that NMRs employ to maintain genome integrity and combat the physiological and pathological decline in organismal function.
- Subjects
AFRICA; NAKED mole rat; CELLULAR aging; NEURODEGENERATION; DNA damage; AGE factors in disease
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 11, p6011
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22116011