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- Title
The Role of Endocan in Selected Kidney Diseases.
- Authors
Nalewajska, Magdalena; Gurazda, Klaudia; Marchelek-Myśliwiec, Małgorzata; Pawlik, Andrzej; Dziedziejko, Violetta
- Abstract
Endocan, previously referred to as an endothelial-cell-specific molecule-1 (ESM-1) is a member of a proteoglycan family that is secreted by vascular endothelial cells of different organs, mainly lungs and kidneys. It is assumed to participate in endothelial activation and the triggering of inflammatory reactions, especially in microvasculatures. Thanks to its solubility in human fluids, i.e., urine and blood plasma, its stability and its low concentrations in physiological conditions, endocan has been proposed as an easily available, non-invasive biomarker for identifying and predicting the course of many diseases. Recently, endocan has been studied in relation to kidney diseases. In general, endocan levels have been linked to worse clinical outcomes of renal dysfunction; however, results are conflicting and require further evaluation. In this review, authors summarize available knowledge regarding the role of endocan in pathogenesis and progression of selected kidney diseases.
- Subjects
KIDNEY diseases; VASCULAR endothelial cells; BLOOD plasma; BIOMARKERS; CHRONIC kidney failure
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 17, p6119
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21176119