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- Title
NADPH Oxidase-Related Pathophysiology in Experimental Models of Stroke.
- Authors
Hiroshi Yao; Tetsuro Ago; Takanari Kitazono; Toru Nabika
- Abstract
Several experimental studies have indicated that nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) exert detrimental effects on ischemic brain tissue; Nox-knockout mice generally exhibit resistance to damage due to experimental stroke following middle cerebral artery occlusion (MCAO). Furthermore, our previous MCAO study indicated that infarct size and blood-brain barrier breakdown are enhanced in mice with pericyte-specific overexpression of Nox4, relative to levels observed in controls. However, it remains unclear whether Nox affects the stroke outcome directly by increasing oxidative stress at the site of ischemia, or indirectly by modifying physiological variables such as blood pressure or cerebral blood flow (CBF). Because of technical problems in the measurement of physiological variables and CBF, it is often difficult to address this issue in mouse models due to their small body size; in our previous study, we examined the effects of Nox activity on focal ischemic injury in a novel congenic rat strain: stroke-prone spontaneously hypertensive rats with loss-of-function in Nox. In this review, we summarize the current literature regarding the role of Nox in focal ischemic injury and discuss critical issues that should be considered when investigating Nox-related pathophysiology in animal models of stroke.
- Subjects
NADPH oxidase; PATHOLOGICAL physiology; CEREBRAL circulation; STROKE; BLOOD-brain barrier; CEREBRAL arterial diseases; ARTERIAL occlusions
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 10, p2123
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18102123