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- Title
Circulating Organ-Specific MicroRNAs Serve as Biomarkers in Organ-Specific Diseases: Implications for Organ Allo- and Xeno-Transplantation.
- Authors
Ming Zhou; Hidetaka Hara; Yifan Dai; Lisha Mou; Cooper, David K. C.; Changyou Wu; Zhiming Cai
- Abstract
Different cell types possess differentmiRNA expression profiles, and cell/tissue/organ-specific miRNAs (or profiles) indicate different diseases. Circulating miRNA is either actively secreted by living cells or passively released during cell death. Circulating cell/tissue/organ-specific miRNA may serve as a non-invasive biomarker for allo- or xeno-transplantation to monitor organ survival and immune rejection. In this review, we summarize the proof of concept that circulating organ-specific miRNAs serve as non-invasive biomarkers for a wide spectrum of clinical organ-specific manifestations such as liver-related disease, heart-related disease, kidney-related disease, and lung-related disease. Furthermore, we summarize how circulating organ-specific miRNAs may have advantages over conventional methods for monitoring immune rejection in organ transplantation. Finally, we discuss the implications and challenges of applying miRNA to monitor organ survival and immune rejection in allo- or xeno-transplantation.
- Subjects
MICRORNA; CELL death; BIOMARKERS; XENOGRAFTS; TRANSPLANTATION of organs, tissues, etc.
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 8, p1232
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17081232