We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Vitamin D Analog, MART-10, Attenuates Triple Negative Breast Cancer Cells Metastatic Potential.
- Authors
Kun-Chun Chiang; Ta-Sen Yeh; Shin-Cheh Chen; Pang, Jong-Hwei S.; Chun-Nan Yeh; Jun-Te Hsu; Li-Wei Chen; Sheng-Fong Kuo; Masashi Takano; Atsushi Kittaka; Chen, Tai C.; Chi-Chin Sun; Horng-Heng Juang
- Abstract
Regarding breast cancer treatment, triple negative breast cancer (TNBC) is a difficult issue. Most TNBC patients die of cancer metastasis. Thus, to develop a new regimen to attenuate TNBC metastatic potential is urgently needed. MART-10 (19-nor-2α-(3-hydroxypropyl)-1α,25(OH)2D3), the newly-synthesized 1α,25(OH)2D3 analog, has been shown to be much more potent in cancer growth inhibition than 1α,25(OH)2D3 and be active in vivo without inducing obvious side effect. In this study, we demonstrated that both 1α,25(OH)2D3 and MART-10 could effectively repress TNBC cells migration and invasion with MART-10 more effective. MART-10 and 1α,25(OH)2D3 induced cadherin switching (upregulation of E-cadherin and downregulation of N-cadherin) and downregulated P-cadherin expression in MDA-MB-231 cells. The EMT(epithelial mesenchymal transition) process in MDA-MB-231 cells was repressed by MART-10 through inhibiting Zeb1, Zeb2, Slug, and Twist expression. LCN2, one kind of breast cancer metastasis stimulator, was also found for the first time to be repressed by 1α,25(OH)2D3 and MART-10 in breast cancer cells. Matrix metalloproteinase-9 (MMP-9) activity was also downregulated by MART-10. Furthermore, F-actin synthesis in MDA-MB-231 cells was attenuated as exposure to 1α,25(OH)2D3 and MART-10. Based on our result, we conclude that MART-10 could effectively inhibit TNBC cells metastatic potential and deserves further investigation as a new regimen to treat TNBC.
- Subjects
BREAST cancer treatment; VITAMIN D; CANCER treatment; METASTASIS; DOWNREGULATION; CANCER invasiveness
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 4, p606
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17040606