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- Title
A Novel Collection of snRNA-Like Promoters with Tissue-Specific Transcription Properties.
- Authors
Garritano, Sonia; Gigoni, Arianna; Costa, Delfina; Malatesta, Paolo; Florio, Tullio; Cancedda, Ranieri; Pagano, Aldo
- Abstract
We recently identified a novel dataset of snRNA-like trascriptional units in the human genome. The investigation of a subset of these elements showed that they play relevant roles in physiology and/or pathology. In this work we expand our collection of small RNAs taking advantage of a newly developed algorithm able to identify genome sequence stretches with RNA polymerase (pol) III type 3 promoter features thus constituting putative pol III binding sites. The bioinformatic analysis of a subset of these elements that map in introns of protein-coding genes in antisense configuration suggest their association with alternative splicing, similarly to other recently characterized small RNAs. Interestingly, the analysis of the transcriptional activity of these novel promoters shows that they are active in a cell-type specific manner, in accordance with the emerging body of evidence of a tissue/cell-specific activity of pol III.
- Subjects
SMALL nuclear RNA; PROMOTERS (Genetics); TISSUE physiology; GENETIC transcription; HUMAN genome; RNA polymerases; NON-coding RNA
- Publication
International Journal of Molecular Sciences, 2012, Vol 13, Issue 9, p11323
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms130911323