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- Title
Exploring the Pharmacological Mechanism of Danzhi Xiaoyao Powder on ER-Positive Breast Cancer by a Network Pharmacology Approach.
- Authors
Yang, Kailin; Zeng, Liuting; Ge, Jinwen
- Abstract
<italic>Background</italic>. Breast cancer is the most common malignancy among women worldwide, but the long-term endocrine therapy is frequently associated with adverse side effects. Danzhi Xiaoyao powder (DXP) is a herbal formula that has an effect on breast cancer, especially ER-positive breast cancer. However, the active compounds, potential targets, and pharmacological and molecular mechanism of its action against cancer remain unclear.<italic> Methods</italic>. A network pharmacology approach comprising drug-likeness evaluation, oral bioavailability prediction, Caco-2 permeability prediction, multiple compound target prediction, multiple known target collection, breast cancer genes collection, and network analysis has been used in this study.<italic> Results</italic>. Four networks are set up—namely, ER-positive breast cancer network, compound-compound target network of DXP, DXP-ER-positive breast cancer network, and compound-known target-ER-positive breast cancer network. Some ER-positive breast cancer and DXP related targets, clusters, biological processes, and pathways, and several potential anticancer compounds are found.<italic> Conclusion</italic>. This network analysis successfully predicted, illuminated, and confirmed the molecular synergy of DXP for ER-positive breast cancer, got potential anticancer active compounds, and found the potential ER-positive breast cancer associated targets, cluster, biological processes, and pathways. This work also provides clues to the researcher who explores ethnopharmacological or/and herbal medicine’s or even multidrugs’ various synergies.
- Subjects
ANTINEOPLASTIC agents; BIOAVAILABILITY; BREAST tumors; CELL lines; CELL receptors; CELLULAR signal transduction; DRUG synergism; HERBAL medicine; INFORMATION storage &; retrieval systems; MEDICAL databases; CHINESE medicine; ONCOGENES; PHARMACOLOGY; POWDERS; PHARMACOKINETICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2018, Vol 2018, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2018/5059743