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- Title
Role of non-canonical post-translational modifications in gastrointestinal tumors.
- Authors
Liu, Yihong; Liu, Jingwei; Peng, Na; Hai, Shuangshuang; Zhang, Shen; Zhao, Haibo; Liu, Weixin
- Abstract
Post-translational modifications (PTMs) of proteins contribute to the occurrence and development of tumors. Previous studies have suggested that canonical PTMs such as ubiquitination, glycosylation, and phosphorylation are closely implicated in different aspects of gastrointestinal tumors. Recently, emerging evidence showed that non-canonical PTMs play an essential role in the carcinogenesis, metastasis and treatment of gastrointestinal tumors. Therefore, we summarized recent advances in sumoylation, neddylation, isoprenylation, succinylation and other non-canonical PTMs in gastrointestinal tumors, which comprehensively describe the mechanisms and functions of non-classical PTMs in gastrointestinal tumors. It is anticipated that targeting specific PTMs could benefit the treatment as well as improve the prognosis of gastrointestinal tumors.
- Subjects
GASTROINTESTINAL tumors; POST-translational modification; ISOPRENYLATION; HUMAN carcinogenesis; UBIQUITINATION
- Publication
Cancer Cell International, 2023, Vol 23, Issue 1, p1
- ISSN
1475-2867
- Publication type
Article
- DOI
10.1186/s12935-023-03062-x