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- Title
SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital.
- Authors
Sotgiu, Giovanni; Barassi, Alessandra; Miozzo, Monica; Saderi, Laura; Piana, Andrea; Orfeo, Nicola; Colosio, Claudio; Felisati, Giovanni; Davì, Matteo; Gerli, Alberto Giovanni; Centanni, Stefano
- Abstract
<bold>Background: </bold>COVID-19 is an infectious disease caused by a novel coronavirus (SARS-CoV-2). The immunopathogenesis of the infection is currently unknown. Healthcare workers (HCWs) are at highest risk of infection and disease. Aim of the study was to assess the sero-prevalence of SARS-CoV-2 in an Italian cohort of HCWs exposed to COVID-19 patients.<bold>Methods: </bold>A point-of-care lateral flow immunoassay (BioMedomics IgM-IgG Combined Antibody Rapid Test) was adopted to assess the prevalence of IgG and IgM against SARS-CoV-2. It was ethically approved ("Milano Area 1" Ethical Committee prot. n. 2020/ST/057).<bold>Results: </bold>A total of 202 individuals (median age 45 years; 34.7% males) were retrospectively recruited in an Italian hospital (Milan, Italy). The percentage (95% CI) of recruited individuals with IgM and IgG were 14.4% (9.6-19.2%) and 7.4% (3.8-11.0%), respectively. IgM were more frequently found in males (24.3%), and in individuals aged 20-29 (25.9%) and 60-69 (30.4%) years. No relationship was found between exposure to COVID-19 patients and IgM and IgG positivity.<bold>Conclusions: </bold>The present study did show a low prevalence of SARS-CoV-2 IgM in Italian HCWs. New studies are needed to assess the prevalence of SARS-CoV-2 antibodies in HCWs exposed to COVID-19 patients, as well the role of neutralizing antibodies.
- Subjects
COVID-19; SARS-CoV-2; SERODIAGNOSIS; COMMUNICABLE diseases; HOSPITALS
- Publication
BMC Pulmonary Medicine, 2020, Vol 20, Issue 1, p1
- ISSN
1471-2466
- Publication type
journal article
- DOI
10.1186/s12890-020-01237-0