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- Title
Prostaglandin E<sub>2</sub>, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles.
- Authors
Dabertrand, Fabrice; Hannah, Rachael M; Pearson, Jessica M; Hill-Eubanks, David C; Brayden, Joseph E; Nelson, Mark T
- Abstract
It has been proposed that prostaglandin E2 (PGE2) is released from astrocytic endfeet to dilate parenchymal arterioles through activation of prostanoid (EP4) receptors during neurovascular coupling. However, the direct effects of PGE2 on isolated parenchymal arterioles have not been tested. Here, we examined the effects of PGE2 on the diameter of isolated pressurized parenchymal arterioles from rat and mouse brain. Contrary to the prevailing assumption, we found that PGE2 (0.1, 1, and 5 μmol/L) constricted rather than dilated parenchymal arterioles. Vasoconstriction to PGE2 was prevented by inhibitors of EP1 receptors. These results strongly argue against a direct role of PGE2 on arterioles during neurovascular coupling.
- Subjects
PROSTAGLANDINS; ASTROCYTES; PROSTANOIDS; EICOSANOIC acid derivatives; NEUROVASCULAR diseases
- Publication
Journal of Cerebral Blood Flow & Metabolism, 2013, Vol 33, Issue 4, p479
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1038/jcbfm.2013.9