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- Title
Tratamiento con kanamicina contra actinomicetomas por Actinomadura madurae.
- Authors
Palma Ramos, Alejandro; Padilla Desgarennes, Carmen; Castrillón Rivera, Laura; Casillas Petriz, Gilberto; Jiménez Zamudio, Luis
- Abstract
Background: Actinomycetoma due to Actinomadura madurae is a chronic infection of skin and adjacent tissues. It is characterized by increased volume and fistulas draining a phyllant exudate, containing the grains. Objetive: To determine the in vitro susceptibility of Actinomadura madurae to kanamycin sulphate, as well as toxicity in infected and non infected murine peritoneal macrophages. Material and method: It was investigated the susceptibility of Actinomadura madurae to several antibiotics —amikacin, erythromycin, ethambutol, kanamycin, penicillin-streptomycin, rifampicin and trimethoprim-sulfamethoxazole—, by antibiogram assay in bacterial cultured in agar and inside phagocytic cells, as well as the toxicity of murine peritoneal macrophages infected and non infected by actinomycetes. The used strains were isolated from five patients of the Mycological Service, of the Dermatological Center Dr. Ladislao de la Pascua, who had mycetoma dye to A. madurae with bone affectation and bad response to conventional treatment. Antibiotic levels in assays were similar to those used in clinical practice, by kg of weight and by day. Results: The most effective antibiotic against these strains was kanamycin. Conclusions: Kanamycicin represents an advisable antibiotic for the treatment of patients with actinomycetomas due to Actinomadura madurae with bone affection, bad prognosis topography and resistance to conventional treatment.
- Subjects
ACTINOMADURA; BACTERIAL disease treatment; DISEASE susceptibility; KANAMYCIN; ANTIBIOTICS; ERYTHROMYCIN; CLINICAL trials; LABORATORY mice
- Publication
Dermatología Revista Mexicana, 2011, Vol 55, Issue 3, p107
- ISSN
0185-4038
- Publication type
Article