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- Title
Immunization with autotransporter Vag8 prevents coughing induced by Bordetella pertussis infection in mice.
- Authors
Suzuki, Koichiro; Hiramatsu, Yukihiro; Nishida, Takashi; Horiguchi, Yasuhiko
- Abstract
Bordetella pertussis causes pertussis, which is characterized by paroxysmal coughing. This disease is generally prevented through vaccination; however, the number of pertussis cases is increasing worldwide despite high vaccination coverage. We previously reported that an autotransporter of B. pertussis, virulence‐associated gene 8 (Vag8), causes coughing in combination with pertussis toxin and lipooligosaccharide. Here, we show that immunization with Vag8 protected mice from coughing after B. pertussis infection and enhanced the efficacy of a current pertussis vaccine containing pertussis toxoid against the cough. Our findings indicate that Vag8 could be a vaccine antigen to prevent pertussis cough.
- Subjects
BORDETELLA pertussis; PERTUSSIS toxin; COUGH; IMMUNIZATION; WHOOPING cough vaccines
- Publication
Microbiology & Immunology, 2023, Vol 67, Issue 6, p314
- ISSN
0385-5600
- Publication type
Article
- DOI
10.1111/1348-0421.13066