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- Title
Antioxidant, anti‐inflammatory, and enzyme inhibitory activity of natural plant flavonoids and their synthesized derivatives.
- Authors
Nile, Shivraj Hariram; Keum, Young Soo; Nile, Arti Shivraj; Jalde, Shivkumar S.; Patel, Rahul V.
- Abstract
Abstract: The synthesized flavonoid derivatives were examined for their antioxidant, anti‐inflammatory, xanthine oxidase (XO), urease inhibitory activity, and cytotoxicity. Except few, all the flavonoids under this study showed significant antioxidant activity (45.6%–85.5%, 32.6%–70.6%, and 24.9%–65.5% inhibition by DPPH, ferric reducing/antioxidant power, and oxygen radical absorption capacity assays) with promising TNF‐α inhibitory activity (42%–73% at 10 μM) and IL‐6 inhibitory activity (54%–81% at 10 μM) compared with that of control dexamethasone. The flavonoids luteolin, apigenin, diosmetin, chrysin, O<italic>3Ꞌ</italic>, <italic>O7</italic>‐dihexyl diosmetin, O<italic>4Ꞌ</italic>, <italic>O7</italic>‐dihexyl apigenin, and <italic>O7</italic>‐hexyl chrysin, showed an inhibition with IC50 values (4.5‐8.1 μg/mL), more than allopurinol (8.5 μg/mL) at 5 μM against XO and showing more than 50% inhibition at a final concentration (5 mM) with an IC50 value of ranging from 4.8 to 7.2 (μg/mL) in comparison with the positive control thiourea (5.8 μg/mL) for urease inhibition. Thus, the flavonoid derivatives may be considered as potential antioxidant and antigout agents.
- Publication
Journal of Biochemical & Molecular Toxicology, 2018, Vol 32, Issue 1, p1
- ISSN
1095-6670
- Publication type
Article
- DOI
10.1002/jbt.22002