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- Title
Tau, prions and Aβ: the triad of neurodegeneration.
- Authors
Reiniger, Lilla; Lukic, Ana; Linehan, Jacqueline; Rudge, Peter; Collinge, John; Mead, Simon; Brandner, Sebastian
- Abstract
This article highlights the features that connect prion diseases with other cerebral amyloidoses and how these relate to neurodegeneration, with focus on tau phosphorylation. It also discusses similarities between prion disease and Alzheimer's disease: mechanisms of amyloid formation, neurotoxicity, pathways involved in triggering tau phosphorylation, links to cell cycle pathways and neuronal apoptosis. We review previous evidence of prion diseases triggering hyperphosphorylation of tau, and complement these findings with cases from our collection of genetic, sporadic and transmitted forms of prion diseases. This includes the novel finding that tau phosphorylation consistently occurs in sporadic CJD, in the absence of amyloid plaques.
- Subjects
PRION diseases; GLYCOPROTEINS; CELLULAR mechanics; APOPTOSIS; CELL death
- Publication
Acta Neuropathologica, 2011, Vol 121, Issue 1, p5
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-010-0691-0