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- Title
Autophagy in immunity and inflammation.
- Authors
Levine, Beth; Mizushima, Noboru; Virgin, Herbert W.
- Abstract
Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is adaptation to nutrient deprivation. However, in complex multicellular organisms, the core molecular machinery of autophagy - the 'autophagy proteins' - orchestrates diverse aspects of cellular and organismal responses to other dangerous stimuli such as infection. Recent developments reveal a crucial role for the autophagy pathway and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.
- Subjects
HOMEOSTASIS; EUKARYOTIC cells; IMMUNITY; ENZYMES; PROTEIN analysis
- Publication
Nature, 2011, Vol 469, Issue 7330, p323
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature09782