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- Title
Tissue preparation: Tissue issues.
- Authors
Blow, Nathan
- Abstract
The article discusses the collected and archived tissue samples from hospitals and tissue banks around the world which were mostly formalin-fixed and paraffin-embedded (FFPE) for future medical research of diseases. The researchers have found out that the tissue samples were well-preserved allowing detailed study of the progression of diseases such as cancer through analysis of biomolecules. As such, pathologists were working towards standardizing FFPE sample preparation while companies and researchers were developing technologies for isolation of biomolecules for accurate results. However, according to David Rimm, pathologist at Yale University that the circulation to fixation could increase promiscuous phosphotases and damage Deoxyribonucleic acid and Ribonucleic acid.
- Subjects
TISSUE analysis; TISSUE preservation; TISSUE banks; MOLECULAR biology; MEDICAL research; BIOMOLECULES; RNA; DNA; GENETIC translation
- Publication
Nature, 2007, Vol 448, Issue 7156, p959
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/448959a